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. 2021 Jan 14;11:1375. doi: 10.1038/s41598-020-80469-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of cortactin, and other pre- and postsynaptic markers at PC-PF synapses. (A) Graph showing the axo-dendritic distribution of gold particles coding for cortactin. Cortactin accumulated at the synapse, extending into the cytoplasmic fringe of the PSD. (See insets for explanation: orange shaded area is presynaptic, while blue is postsynaptic) (B) Axo-dendritic distribution of gold particles coding for synaptophysin, and PSD-95. Synaptophysin concentrated presynaptically, while PSD-95 was highly restricted to the postsynapse. (See insets for explanation) (C) Radial distribution of particles coding for cortactin. Radial distances of gold particles coding for cortactin from the closest membrane of spine heads were shown in the graph as proportions. Most cortactin particles were found in the immediate vicinity of the non-synaptic membrane. (D) Normalized distribution of cortactin shows that cortactin, independent of spine size, is restricted to the submembrane domain while particles from samples containing normal rabbit serum as control were found to be distributed more evenly within the spinoplasm. Data are from 195 profiles for cortactin, 45 for synaptophysin, and 45 for PSD-95. The bin width was 35 nm for (A), 20 nm for (B,C), and 0.05 normalized unit for (D). In D data were smoothed with a three-point weighted running average.

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