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. 2021 Jan 9;14:100293. doi: 10.1016/j.ynstr.2021.100293

Fig. 4.

Fig. 4

Effects of selective inhibitors of FAAH and MAGL on anxiety-like behavior and locomotor activity. Effects of the selective FAAH inhibitor PF-3845 on the time spent in open arms (A) and the number of entries in the closed arms (B) in the EPM with WT mice (n = 9–10 per group). Effects of the selective MAGL inhibitor JZL184 on the time spent in open arms (C) and the number of entries in the closed arms (D) in the EPM with WT mice (n = 10–11 per group). Effects of the selective FAAH inhibitor PF-3845 on the time spent in the light compartment (E) and the number of transitions between light and dark compartments (F) in the LDT with WT mice (n = 10 per group). Effects of the selective MAGL inhibitor JZL184 on the time spent in the light compartment (G) and the number of transitions between light and dark compartments (H) in the LDT with WT mice (n = 8–11 per group). Bars are mean and SEM. Symbols in the bars denote significant differences in the post hoc test after one-way ANOVA: (*) p < 0.05, (**) p < 0.01 and (***) p < 0.001 denote significant differences vs. the vehicle group; (a) p < 0.05 and (aaa) p < 0.001 denote significant differences vs. the low-dose group; (b) p < 0.05 denotes significant differences vs. the intermediate-dose group.