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. 2021 Jan 14;41(1):BSR20202583. doi: 10.1042/BSR20202583

Table 1. Pharmacokinetic parameters of compounds.

Compound OB(%) DL BBB HL RBN
Rutin 3.20 0.68 -2.75 - 6
Matrine 63.77 0.25 1.52 6.69 0
Melanin 26.40 0.67 -0.63 - 0
Luteolin 36.16 0.25 -0.84 15.94 1
Caffeine 89.46 0.08 -0.01 13.64 0
Aucubin 4.17 0.33 -2.90 - 4
Piperine 42.52 0.23 0.62 10.25 3
Wogonin 30.68 0.23 0.04 17.75 2
Daidzein 19.44 0.19 -0.22 - 1
Myricetin 13.75 0.31 -1.01 - 1
Quercetin 46.43 0.28 -0.77 14.40 1
Ursolic acid 16.77 0.75 0.07 - 1
Resveratrol 19.07 0.11 -0.01 - 2
Paeoniflorin 53.87 0.79 -1.86 13.88 7
Sinomenine 30.98 0.46 0.43 1.79 2
Atractylenolide I 37.37 0.15 1.29 7.10 0
γ-aminobutyric acid 24.09 0.01 -0.57 - 3

Abbreviations: BBB, blood–brain barrier; DL, drug-likeness; HL, half-life; OB, oral bioavailability; RBN, rotatable bond number.