Table 1. Pharmacokinetic parameters of compounds.

Compound	OB(%)	DL	BBB	HL	RBN
Rutin	3.20	0.68	-2.75	-	6
Matrine	63.77	0.25	1.52	6.69	0
Melanin	26.40	0.67	-0.63	-	0
Luteolin	36.16	0.25	-0.84	15.94	1
Caffeine	89.46	0.08	-0.01	13.64	0
Aucubin	4.17	0.33	-2.90	-	4
Piperine	42.52	0.23	0.62	10.25	3
Wogonin	30.68	0.23	0.04	17.75	2
Daidzein	19.44	0.19	-0.22	-	1
Myricetin	13.75	0.31	-1.01	-	1
Quercetin	46.43	0.28	-0.77	14.40	1
Ursolic acid	16.77	0.75	0.07	-	1
Resveratrol	19.07	0.11	-0.01	-	2
Paeoniflorin	53.87	0.79	-1.86	13.88	7
Sinomenine	30.98	0.46	0.43	1.79	2
Atractylenolide I	37.37	0.15	1.29	7.10	0
γ-aminobutyric acid	24.09	0.01	-0.57	-	3

Abbreviations: BBB, blood–brain barrier; DL, drug-likeness; HL, half-life; OB, oral bioavailability; RBN, rotatable bond number.