Figure 2.

Position of Identified SDRs along the Kinase Sequence and Structure

All putative kinase SDRs from this analysis are (A) listed in a table with their corresponding position preferences, (B) mapped to a 1-dimensional (1D) representation of the kinase secondary structure, and (C) mapped to a kinase-substrate complex structure (PDB: 1ATP). The SDRs colored in dark red (B) and (C) represent positions within 4 Å of the substrate peptide. Residue numbering represents the relevant positions of the Pfam protein kinase domain (PF00069). The numbers in brackets for (A) represent the number of kinases with the given specificity.