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. Author manuscript; available in PMC: 2021 Jun 29.
Published in final edited form as: J Alzheimers Dis. 2021;82(Suppl 1):S335–S357. doi: 10.3233/JAD-200185

Fig. 2.

Fig. 2.

Cu binding interactions with AβPP and Aβ42. a) Configuration of Cu with residues His147, His151, Tyr168 in APP’s copper binding region and two water molecules in a trigonal bipyramidal geometry. b) Configuration of Cu with residues His388, His457, His507, and His511 in APP E2 domain. c) Cu binding with Aβ42 residues Ala2, His6, His13, and His14 in a tetrahedral square planar configuration. d) Cu binding to Aβ42 residues His6, Tyr10, His13, His14, and a water molecule in a trigonal bipyramidal configuration. e) Square-base pyramidal arrangement of Cu with Aβ42 residues Asp1, His6, His 13 or 14, and the carboxylate of Asp1, Glu3, Asp7, or Glu11.