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. 2021 Jan 12;34(2):108615. doi: 10.1016/j.celrep.2020.108615

Figure 2.

Figure 2

β-Secretase and γ-Secretase Inhibition Differentially Affect Neurogenesis

(A) Representative images of day 27 iPSC-derived neural precursors treated with β-secretase inhibitor (BSI; LY2886721, 1 μM), vehicle (DMSO), and γ-secretase inhibitor (GSI; DAPT, 10 μM). Ki67 marks dividing cells, and TUJ1 depicts terminally differentiated neurons.

(B–D) Quantification of 6 independent inductions and the effect of β- and γ-secretase inhibition on total cell number, dividing cells (Ki67), and TUJ1 postmitotic neurons via high-content imaging.

∗p < 0.05, ∗∗p < 0.01 via ANOVA with post hoc Tukey’s analysis, as indicated in Table S1. Scale bar represents 50 μm. Error bars represent standard error of the mean.