Figure 5.

Expression of Notch Signaling Components and AD-Related Genes in the Mouse Adult Hippocampal Neurogenic Lineage

(A) Low-dimensional representation of transcriptional space (UMAP plot), showing single-cell transcriptomes of adult hippocampal neural stem cells (AH-NSCs, green), intermediate neuronal progenitor cells (IPCs, blue), and granule neurons (red) derived from the hippocampus of postnatal mice from a publicly available dataset (Hochgerner et al., 2018).

(B) Expression of the Notch signaling target gene Fabp7 is higher in NSCs than in neurons.

(C–E) γ-secretase genes Psen1 and Psen2 are expressed in all cell types but below the threshold for differential gene expression analyses. The Psenen subunit of γ-secretase is significantly higher in NSCs than in neurons.

(F) Expression of App is enriched in neurons compared with NSCs.

(G) Expression of the β-secretase gene Bace1 is enriched in neurons.

Wilcoxon rank-sum test, with the genome-wide false discovery rate (FDR)-corrected p value in (B)–(G). ^∗∗∗p < 0.001, n.s., p > 0.05.