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. 2021 Jan 12;34(2):108615. doi: 10.1016/j.celrep.2020.108615

Figure 6.

Figure 6

Analysis of Neurogenesis in Mutation-Confirmed fAD Postmortem Hippocampal Tissue

(A) TUJ1-positive projections (black arrows) crossing the granule layer of the dentate gyrus in the hippocampus, employed as a marker for newly generated neurons.

(B) Quantification of newborn neurons in the hippocampi per 200 μm.

(C) NESTIN was used as a marker for NSCs.

(D) Quantification of the number of NESTIN-positive cells in contact with the granule layer of the dentate gyrus per 200 μm.

(E) Correlation of TUJ1 fibers (newborn neurons) with age at death per case. The black line is the regression line for all data.

(F) Correlation of TUJ1 fibers (newborn neurons) with disease duration. The black line is the regression line for all data.

Scale bar represents 100 μm. ∗∗p < 0.01 via ANOVA with post hoc Tukey’s analysis, as indicated in Table S1. R-squared values are shown in Table S1. Comparisons represent multiple fields of view for each brain (n = 1). Blue, control; purple, APP V717I; pink, mutations in the PSEN1 extracellular loop; green, mutations in PSEN1 transmembrane and intracellular domains. Error bars represent standard error of the mean.