Table 2.
Meta-analyses for the frequency of clinical symptoms in coronavirus disease 2019 cases from China and North America
| Symptoms |
China
|
North America
|
P
2
value
|
||||||||||
| Number of cases (n)1 |
Meta-analysis
|
Heterogenicity
|
Number of cases (n) |
Meta-analysis
|
Heterogenicity
|
||||||||
|
Frequency (%)
|
95%CI
|
τ
2
|
Q
|
I
2
|
Frequency (%)
|
95%CI
|
τ
2
|
Q
|
I
2
|
||||
| Fever | 25223 | 77.5 | 75.8-79.2 | 0.015 | 3591 | 93 | 4,502 | 43.3 | 30.8-56.1 | 0.099 | 5023 | 96 | < 0.001 |
| Cough | 24105 | 59.6 | 56.9-62.4 | 0.041 | 4843 | 95 | 3766 | 58.3 | 44.7-71.9 | 0.951 | 1997 | 98 | 0.131 |
| Dyspnea | 20558 | 29.4 | 26.7-32.1 | 0.028 | 9566 | 98 | 3711 | 38.9 | 24.3-53.5 | 0.103 | 4636 | 99 | < 0.001 |
| Headache | 13627 | 9.8 | 8.6-11.1 | 0.003 | 726 | 85 | 2483 | 8.9 | 6.4-11.4 | 0.001 | 36 | 64 | 0.163 |
| Expectoration | 14426 | 28.1 | 25.3-30.7 | 0.018 | 1719 | 93 | 2024 | 8.2 | 5.5-10.9 | 0.002 | 14 | 72 | < 0.001 |
| Myalgia | 16.184 | 19.1 | 17.1-21.2 | 0.012 | 3596 | 96 | 1224 | 22.5 | 12.8-32.3 | 0.019 | 159 | 94 | < 0.001 |
| Fatigue | 19561 | 36.3 | 33.2-39.4 | 0.038 | 5004 | 97 | 21 | 48.3 | 20.1-76.5 | 0.032 | 4 | 51 | 0.253 |
| Diarrhea | 20535 | 10.4 | 9.3-11.6 | 0.004 | 2210 | 92 | 3719 | 12.9 | 7.6-18.2 | 0.012 | 538 | 96 | < 0.001 |
| Vomiting and nausea | 14974 | 7.2 | 6.1-8.3 | 0.003 | 1485 | 91 | 2198 | 11.6 | 6.1-17.1 | 0.006 | 108 | 91 | < 0.001 |
| Sore throat | 11379 | 9.1 | 7.7-10.4 | 0.002 | 476 | 84 | 2542 | 8.3 | 6.8-9.8 | 0.001 | 16 | 23 | 0.202 |
| Chills | 5949 | 7.5 | 5.2-9.8 | 0.003 | 386 | 94 | 2108 | 17.7 | 16.1-19.3 | 0.001 | 5 | 18 | < 0.001 |
1
n is the number of subjects assessed for each clinical symptom as per the source database[7].
2
Chi Square test for the difference between symptom frequency in China and North America.