Table 1.
Baseline characteristics of EXTEND45 participants who were at risk of developing incident eGFR <60 mL/min/1.73 m2
| Baseline characteristics | Diabetes with no incident eGFR <60 mL/min/1.73 m2 (n = 7,207) | Diabetes with incident eGFR <60 mL/min/1.73 m2 (n = 2,106) | All (n = 9,313) |
|---|---|---|---|
| Age (years), mean (SD) | 63.9 (9.3) | 70.5 (9.4) | 65.4 (9.7) |
| Male | 3,976/7,207 (55.2) | 1,165/2,106 (55.3) | 5,141/9,313 (55.2) |
| Diabetes status at 45 and Up enrollment | |||
| Prevalent | 3,584/7,207 (49.7) | 1,521/2,106 (72.2) | 5,105/9,313 (54.8) |
| Incident (during follow-up) | 3,623/7,207 (50.3) | 585/2,106 (27.8) | 4,208/9,313 (45.2) |
| Diabetes duration (years), mean (SD) | 1.53 (2.310) | 2.63 (2.647) | 1.78 (2.434) |
| Diabetes duration >5 years | 931/7,207 (12.9) | 508/2,106 (24.1) | 1,439/9,313 (15.5) |
| Baseline eGFR (mL/min/1.73 m2), mean (SD) | 83.55 (16.014) | 72.12 (9.758) | 80.96 (15.583) |
| Baseline eGFR >90 mL/min/1.73 m2 | 2,232/7,207 (31.0) | 136/2,106 (6.5) | 2,368/9,313 (25.4) |
| Baseline eGFR 60–89 mL/min/1.73 m2 | 4,975/7,207 (69.0) | 1,970/2,106 (93.5) | 6,945/9,313 (74.6) |
| Hypertension, present | 5,019/7,207 (69.6) | 1,817/2,106 (86.3) | 6,836/9,313 (73.4) |
| Hypercholesterolemia, present | 4,587/7,207 (63.6) | 1,539/2,106 (73.1) | 6,126/9,313 (65.8) |
| CHD, present | 1,361/7,207 (18.9) | 652/2,106 (31.0) | 2,013/9,313 (21.6) |
| Previous stroke | 301/7,207 (4.2) | 149/2,106 (7.1) | 450/9,313 (4.8) |
| Prior or current cancer | 503/7,207 (7.0) | 242/2,106 (11.5) | 745/9,313 (8.0) |
| Prior or current depression | 1,390/7,207 (19.3) | 404/2,106 (19.2) | 1,794/9,313 (19.3) |
| Country of birth | |||
| Europe | 1,229/7,207 (17.1) | 353/2,106 (16.8) | 1,582/9,313 (17.0) |
| Australia | 4,957/7,207 (68.8) | 1,567/2,106 (74.4) | 6,524/9,313 (70.1) |
| New Zealand and Polynesia | 164/7,207 (2.3) | 27/2,106 (1.3) | 191/9,313 (2.1) |
| Africa and the Middle East | 199/7,207 (2.8) | 41/2,106 (1.9) | 240/9,313 (2.6) |
| Asia | 482/7,207 (6.7) | 76/2,106 (3.6) | 558/9,313 (6.0) |
| Americas | 103/7,207 (1.4) | 19/2,106 (0.9) | 122/9,313 (1.3) |
| Inadequately described or missing | 73/7,207 (1.0) | 23/2,106 (1.1) | 96/9,313 (1.0) |
| Area of residence | |||
| Major city | 4,806/7,119 (67.5) | 1,247/2,074 (60.1) | 6,053/9,193 (65.8) |
| Inner regional | 1,744/7,119 (24.5) | 594/2,074 (28.6) | 2,338/9,193 (25.4) |
| Outer regional and remote | 569/7,119 (8.0) | 233/2,074 (11.2) | 802/9,193 (8.7) |
| Highest qualification | |||
| No school certificate | 1,051/7,088 (14.8) | 382/2,054 (18.6) | 1,433/9,142 (15.7) |
| School or intermediate certificate | 1,585/7,088 (22.4) | 549/2,054 (26.7) | 2,134/9,142 (23.3) |
| Higher School Certificate | 727/7,088 (10.3) | 210/2,054 (10.2) | 937/9,142 (10.2) |
| Trade or apprenticeship | 840/7,088 (11.9) | 266/2,054 (13.0) | 1,106/9,142 (12.1) |
| Certificate or diploma | 1,374/7,088 (19.4) | 344/2,054 (16.7) | 1,718/9,142 (18.8) |
| University degree or higher | 1,511/7,088 (21.3) | 303/2,054 (14.8) | 1,814/9,142 (19.8) |
| Household income | |||
| Less than $20,000 | 1,581/6,833 (22.2) | 651/1,957 (33.2) | 2,232/8,790 (25.4) |
| $20,000 to <50,000 | 1,697/6,833 (24.8) | 552/1,957 (28.2) | 2,249/8,790 (25.6) |
| $50,000 to <70,000 | 748/6,833 (10.9) | 151/1,957 (7.7) | 899/8,790 (10.2) |
| $70,000 and over | 1,552/6,833 (22.7) | 222/1,957 (11.3) | 1,774/8,790 (20.2) |
| Partner status | |||
| Partner | 5,458/7,154 (76.3) | 1,450/2,089 (69.4) | 6,908/9,243 (74.7) |
| No partner | 1,696/7,154 (23.7) | 639/2,089 (30.6) | 2,335/9,243 (25.3) |
| Level of disadvantage | |||
| Q1 (most disadvantaged) | 1,526/7,064 (21.6) | 524/2,056 (25.5) | 2,050/9,120 (22.5) |
| Q2 | 1,300/7,064 (18.4) | 421/2,056 (20.5) | 1,721/9,120 (18.9) |
| Q3 | 1,297/7,064 (18.4) | 371/2,056 (18.0) | 1,668/9,120 (18.3) |
| Q4 | 1,196/7,064 (16.9) | 320/2,056 (15.6) | 1,516/9,120 (16.6) |
| Q5 (least disadvantaged) | 1,745/7,064 (24.7) | 420/2,056 (20.4) | 2,165/9,120 (23.7) |
| Smoking status | 636/7,181 (8.9) | 101/2,097 (4.8) | 737/9,278 (7.9) |
| Current | 2,884/7,181 (40.2) | 920/2,097 (43.9) | 3,804/9,278 (41.0) |
| Previous | 3,661/7,181 (51.0) | 1,076/2,097 (51.3) | 4,737/9,278 (51.1) |
| Never | 636/7,181 (8.9) | 101/2,097 (4.8) | 737/9,278 (7.9) |
| Alcohol consumption (number of standard drinks/week) | |||
| 0 | 2,885/7,021 (41.1) | 965/2,032 (47.5) | 3,850/9,053 (42.5) |
| 1–6 | 1,925/7,021 (27.4) | 507/2,032 (25.0) | 2,432/9,053 (26.9) |
| 7–13 | 1,030/7,021 (14.7) | 254/2,032 (12.5) | 1,284/9,053 (14.2) |
| 14–20 | 635/7,021 (9.0) | 160/2,032 (7.9) | 795/9,053 (8.8) |
| Over 21 | 546/7,021 (7.8) | 146/2,032 (7.2) | 692/9,053 (7.6) |
| BMI | |||
| <18.5 kg/m2 | 40/6,698 (0.6) | 11/1,927 (0.6) | 51/8,625 (0.6) |
| 18.5 to <25 kg/m2 | 1,267/6,698 (18.9) | 329/1,927 (17.1) | 1,596/8,625 (18.5) |
| 25 to <30 kg/m2 | 2,497/6,698 (37.3) | 741/1,927 (38.5) | 3,238/8,625 (37.5) |
| 30 to <35 kg/m2 | 1,746/6,698 (26.1) | 513/1,927 (26.6) | 2,259/8,625 (26.2) |
| 35 to <40 kg/m2 | 707/6,698 (10.6) | 216/1,927 (11.2) | 923/8,625 (10.7) |
| ≥40 kg/m2 | 441/6,698 (6.6) | 117/1,927 (6.1) | 558/8,625 (6.5) |
Data are n/n (%) unless otherwise noted.