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. 2020 Dec 1;40(2):e104450. doi: 10.15252/embj.2020104450

Figure EV4. Internalization of 5xFAD hAPP in mouse hippocampal neurons from p75NTR mutant mice in the presence and absence of NGF.

Figure EV4

  • A, C, E
    Internalization of hAPP in hippocampal neurons from knock‐out (A) ΔDD (C) and C259A (E) mice. Shown are averages ± SEM of percentage internalization of total surface hAPP (set to 100%). N = 3 independent experiments each performed in duplicate.
  • B, D, F
    Linear transformation of hAPP internalization kinetics shown in panels (A, C, and E) respectively. IMAX denotes maximal internalization in %. T1/2 denotes time for half maximal internalization (in minutes).