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. 2021 Jan 14;21:54. doi: 10.1186/s12935-021-01749-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Down-regulation of circ_0007534 repressed CC cell growth and invasion but facilitated apoptosis. a The qRT-PCR indicated that the interference efficiency of si-circ_0007534 was successful. b, c MTT displayed that si-circ_0007534 suppressed cell viability in SiHa (b) and HeLa (c) cells contrasted to si-NC. d, e Colony formation assay exhibited that si-circ_0007534 reduced cell proliferation contrasted to si-NC. f, g Flow cytometry demonstrated that si-circ_0007534 enhanced cell apoptosis contrasted to si-NC. h, i Western blot for apoptotic protein detection confirmed that cell apoptosis was promoted by si-circ_0007534 compared with si-NC. j, k Transwell assay suggested that cell invasion was inhibited by si-circ_0007534 compared with si-NC. NC negative control, OD optical density, Bcl-2 B-cell lymphoma-2, Bax Bcl-2-Associated X, C-Caspase3 Cleaved-Caspase3, GAPDH glyceraldehyde-phosphate dehydrogenase. All assays were performed for three times with technical n = 3. Statistical analysis was conducted by Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001