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. 2021 Jan 14;21:54. doi: 10.1186/s12935-021-01749-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Overexpression of circ_0007534 relieved the miR-206-induced effects on CC cells by acting as a sponge of miR-206. a The qRT-PCR demonstrated that the miR-206-mediated high miR-206 expression was inhibited by circ_0007534 in SiHa and HeLa cells. (b-d) MTT and colony formation assay proved that circ_0007534 promoted cell viability (b, c) and proliferation (d) by upregulating the expression of miR-206. (e–g) Flow cytometry (e) and western blot (f, g) were performed to verify the regulation of circ_0007534/miR-206 axis in cell apoptosis. h Transwell assay validated that circ_0007534 facilitated cell invasive ability by targeting miR-206. NC negative control, OD optical density, Bcl-2 B-cell lymphoma-2, Bax Bcl-2-Associated X, C-Caspase3 Cleaved-Caspase3, GAPDH glyceraldehyde-phosphate dehydrogenase. All assays were performed for three times with technical n = 3. Statistical analysis was conducted by Student’s t-test and one-way analysis of variance followed by Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001