Fig. 7.

Inhibition of circ_0007534 reduced tumor growth partly by increasing miR-206 and downregulating GREM1 in vivo. (a, b) Knockdown of circ_0007534 reduced tumor volume (a) and weight (b) in mice. c The qRT-PCR was used to reveal the downregulation of circ_0007534, GREM1 and overexpression of miR-206 by silence of circ_0007534 in tumor tissues. d The protein level of GREM1 by western blot was decreased after circ_0007534 knockdown in tumor tissues. NC negative control, GREM1 Gremlin1. All assays were performed for three times with technical n = 3. Statistical analysis was conducted by Student’s t-test and one-way analysis of variance followed by Tukey’s test. *P < 0.05, **P < 0.01