Figure 10.
Effect of aPLs on diverse viral K+ channels. (A) Representative single-channel fluctuations of channels indicated on the left at ±120 mV in bilayers with only DPhPC or in bilayers containing a 1:1 mix of DPhPC:DPhPS. Closed (C) and open (O) levels are indicated. (B and C) Mean single-channel I/V relations (B) and PO/V relations (C) for channels in the same row from recordings in DPhPC (black) or DPhPC:DPhPS (red) bilayers. Data in B and C are mean values ± SD from n independent measurements of channel X in NDPhPC/NDPhPC:DPhPS. KcvNTS: 6/7, KcvPBCV1: 8/6, Kmpv12T: 10/8, KcvGLD: 7/3, KcvMT325: 5/3.