Table 1. Effect of cholesterol on conductance (G) and open probability (PO) of channels ±30 mol% cholesterol (Chol) in DPhPC bilayers.
| Channel | Chol mol% | N | G/pS | PO −100 mV |
|---|---|---|---|---|
| KcvS | 0 | 10 | 92 ± 9 | 0.40 ± 0.01 |
| KcvS | 30 | 4 | 100 ± 12 | 0.53 ± 0.08 |
| KcvNTS | 0 | 6 | 82 ± 12 | 0.93 ± 0.01 |
| KcvNTS | 30 | 4 | 97 ± 8 | 0.91 ± 0.04 |
| Kmpv12T | 0 | 10 | 37 ± 5 | 0.21 ± 0.08 |
| Kmpv12T | 30 | 3 | 51 ± 9a | 0.52 ± 0.16a |
G measured as slope conductance between ±60 mV. Open probability is presented for each channel for the critical voltage of −100 mV at which a possible effect of cholesterol on PO is most visible. Data are represented as mean ± SD of n independent bilayer recordings.
a
The significance for a difference in G and PO values ± Chol is indicated with P values <0.01.