Table 2. Effect of aPLs on conductance (G) and open probability (PO) of K+ channels in lipid bilayers.
Channel | Bilayer | N | G/pS | PO |
---|---|---|---|---|
KcvS | PC | 10 | 92 ± 9 | −100 mV: 0.40 ± 0.10 |
KcvS | PS | 9 | 120 ± 6a | −100 mV: 0.89 ± 0.06a |
KcvNTS | PC | 6 | 82 ± 12 | −100 mV: 0.93 ± 0.01 |
KcvNTS | PS | 7 | 107 ± 5a | −100 mV: 0.97 ± 0.01a |
KcvPBCV1 | PC | 8 | 139 ± 11 | +100 mV: 0.01 ± 0.004 |
KcvPBCV1 | PS | 6 | 191 ± 11a | +100 mV: 0.12 ± 0.10a |
KcvNH | PC | 3 | 98 ± 2 | +60 mV: 0.47 ± 0.02 |
KcvNH | PS | 3 | 138 ± 4a | +60 mV: 0.72 ± 0.06a |
KcvMT325 | PC | 15 | 34 ± 6 | +160 mV: 0.59 ± 0.14 |
KcvMT325 | PG | 10 | 47 ± 6a | +160 mV: 0.70 ± 0.08 |
KcvGLD | PC | 7 | 38 ± 4 | +160 mV: 0.72 ± 0.07 |
KcvGLD | PG | 9 | 91 ± 16a | +160 mV: 0.44 ± 0.05 |
Kmpv12T | PC | 10 | 37 ± 5 | −100 mV: 0.21 ± 0.08 |
Kmpv12T | PS | 4 | 62 ± 4a | −100 mV: 0.10 ± 0.05 |
G measured as slope conductance between ± 60 mV. Open probability is presented for each channel for the indicated critical voltage at which a possible difference in PO ± aPLs is most visible. Data are represented as mean ± SD of n independent bilayer recordings.
The significance for a difference in G and PO values for PC and PS/PG bilayers is indicated with P values <0.001.