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. 2021 Jan 5;23(3):188. doi: 10.3892/mmr.2021.11827

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Nogo-66 inhibits neurite outgrowth and promotes Aβ secretion in primary cortical neurons. (A) Immune-fluorescence micrographs of microtubule-associated protein 2 in cultured neurons treated with different concentrations of Nogo-66. (a) PBS (vehicle control); (b) 0.25 µM Nogo-66; (c) 0.5 µM Nogo-66; (d) 1 µM Nogo-66. Scale bar, 30 µm. (B) Semi-quantification of neurite outgrowth in (A). Data are presented as the mean ± SD (n=8). ***P<0.001 vs. the PBS group. Nogo-66 induced (C) Aβ₄₀ and (D) Aβ₄₂ production in a dose-dependent manner in cortical neurons. Data are presented as the mean ± SD (n=4). **P<0.01, ***P<0.001 vs. control. Aβ, β-amyloid protein.