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. 2021 Jan 5;23(3):188. doi: 10.3892/mmr.2021.11827

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — NEP1-40 or Y-27632 overcome Nogo-66-induced production of Aβ₄₀ and Aβ₄₂ in cortical neurons and N2a cells. NEP1-40 and Y-27632 decreased the levels of (A) Aβ₄₀ and (C) Aβ₄₂ in cortical neurons. NEP1-40 and Y-27632 decreased the levels of (B) Aβ₄₀ and (D) Aβ₄₂ in N2a cells. Data are presented as the mean ± SD (n=6). ^###P<0.001 vs. control; **P<0.01 vs. control; ***P<0.001 vs. Nogo-66 group. NEP1-40, Nogo-66 antagonist peptide; N2a, Neuro2a; Aβ, β-amyloid protein.