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Proposed schematic working model: Nogo-66 promotes Aβ secretion through the NgR/ROCK/BACE1 pathway. Aβ, β-amyloid protein; ROCK, Rho-associated coiled-coil containing kinase; BACE1, β-secretase 1; APP, amyloid precursor protein; sAPP, secreted APP; NgR, Nogo-66 receptor.
