Table 1.
Demographic, clinical, virological features and gene expression data (GUS, ACE2, furin, ISG15) of study patients (n = 107).
| Items | Total patients n = 107 |
Children n = 59 |
Adults n = 48 |
|---|---|---|---|
| Age (years)* | 28.34 ± 32.29 | 1.21 ± 2.45 | 61.67 ± 16.91 |
| Male (%) | 69/107 (64.5%) | 38/59 (55.1%) | 31/48 (44.9%) |
| Virus positive | 64/107 (59.8%) | 54/59 (91.5%) | 10/48 (20.83%)● |
| RSV | 29/64 (45.3%) | 28/54 (51.9%) | 1/10 (10%) |
| HRV | 18/64 (28.1%) | 16/54 (29.6%) | 2/10 (20%) |
| HKU1 | 5/64 (7.8%) | 2/54 (3.7%) | 3/10 (30%) |
| FLU A | 6/64 (9.4%) | 5/54 (9.3%) | 1/10 (10%) |
| HMPV | 1/64 (1.6%) | 0/54 (0%) | 1/10 (10%) |
| Coinfections | 5/64 (7.8%) | 3/54 (5.5%) | 2/10 (20%) |
| Gene expression | |||
| GUS** | 34.62 ± 3.67 | 34.12 ± 3.83 | 35.24 ± 3.40 |
| ACE2*** | 0.01 (0.002–0.06) | 0.03 (0.006–0.14) | 0.006 (0.0008–0.02) |
| Furin*** | 0.006 (0.0006–0.02) | 0.006 (0.001–0.026) | 0.004 (0.0005–0.01) |
| ISG15*** | 7.01 (1.88–52.71) | 41.07 (7.49–213.79) | 2.03 (0.88–4.83)▾ |
*Age is expressed as mean ± SD. **Ct (threshold cycle) values of GUS (beta-glucuronidase gene) are indicated as mean ± SD. ***Transcript levels of ISG15, ACE2 and furin, calculated using 2-ΔCt, are indicated as median (interquartile range = IQR).
●p < 0.001 by Chi-Squared test; ▾p < 0.001 by Mann-Whitney U test.