. 2020 Nov-Dec;65(6):443–449. doi: 10.4103/ijd.IJD_291_20

Table 3.

Chemical leucoderma syndrome (CLS)[3]

Stage I. Chemical leucoderma only at the site of contact

Stage II. Local spread of chemical leucoderma through the lymphatics beyond the site of contact

Stage IIIA. Distant spread of chemical leucoderma through hematogenous spread beyond the site of contact

Stage IIIB. Distant spread of chemical leucoderma through hematogenous spread beyond the site of contact along with systemic organ involvement

Stage IIIC^a. Systemic introduction (injection, inhalation or ingestion) other than skin contact causing chemical leucoderma with or without systemic organ involvement

Stage IV. Distant spread of vitiligo-like patches even after 1 year of strictly withholding exposure to offending chemicals (‘chemical vitiligo’)

^aThis stage is a hypothesis or probability; not yet proved.