Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Examples of inflammatory pathways within endothelial cells during sepsis (TLR4 and TNF-α). LPS and cytokines trigger intracellular pathways that ultimately lead to the activation of number of transcription factors (NF-κB, AP-1, and IRF3), resulting in increased cytokine production and adhesion molecule expression. These pathways also likely contribute to mitochondrial dysfunction and ROS production (see text for details).
