Table 3.
Adjusted association of dichotomized metabolic syndrome components with standardized continuous measures of global brain amyloid standardized uptake value ratio (SUVR) and cortical thickness in AD signature regions (n=350)
| Exposure Group | n | Global Brain Amyloid SUVR | AD Signature Region Cortical Thickness |
|---|---|---|---|
| Glucose | |||
| Normal | 191 | Reference | Reference |
| High | 159 | −0.22 (−0.42, −0.02)* | −0.15 (−0.35, 0.06) |
| Waist Circumference | |||
| Healthy | 133 | Reference | Reference |
| High | 217 | 0.02 (−0.20, 0.24) | −0.10 (−0.32, 0.12) |
| Triglycerides | |||
| Healthy | 274 | Reference | Reference |
| High | 76 | −0.04 (−0.28, 0.20) | −0.14 (−0.39, 0.11) |
| HDL Cholesterol | |||
| Healthy | 224 | Reference | Reference |
| Low | 126 | 0.12 (−0.08, 0.33) | 0.02 (−0.19, 0.23) |
| Systolic Blood Pressure | |||
| Healthy | 99 | Reference | Reference |
| High | 251 | 0.01 (−0.22, 0.24) | −0.06 (−0.29, 0.17) |
| Diastolic Blood Pressure | |||
| Healthy | 119 | Reference | Reference |
| High | 231 | −0.01 (−0.22, 0.21) | −0.03 (−0.25, 0.19) |
Note: Estimates are βetas (95% Confidence Interval)
Models adjusted for age, sex, and APOE-ε4
a
Indicates significant result after adjustment for multiple comparisons (p<0.0083 by Bonferroni correction (6 tests))
*
p<0.05 before accounting for multiple comparisons