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. 2020 Jun 23;10(40):24017–24026. doi: 10.1039/d0ra04110f

Deprotection of structurally diverse N-Boc-amines.

Entrya Substrate (a) Time/h Product (b) Yield (%)
1 graphic file with name d0ra04110f-u1.jpg 2 graphic file with name d0ra04110f-u2.jpg 70
2 graphic file with name d0ra04110f-u3.jpg 1.5 graphic file with name d0ra04110f-u4.jpg 87
3 graphic file with name d0ra04110f-u5.jpg 1.5 graphic file with name d0ra04110f-u6.jpg 83
4 graphic file with name d0ra04110f-u7.jpg 1 graphic file with name d0ra04110f-u8.jpg 80
5 graphic file with name d0ra04110f-u9.jpg 2 graphic file with name d0ra04110f-u10.jpg 83
6 graphic file with name d0ra04110f-u11.jpg 3 graphic file with name d0ra04110f-u12.jpg 78
7 graphic file with name d0ra04110f-u13.jpg 1.5 graphic file with name d0ra04110f-u14.jpg 76
8 graphic file with name d0ra04110f-u15.jpg 1.5 graphic file with name d0ra04110f-u16.jpg 81
9 graphic file with name d0ra04110f-u17.jpg 1 graphic file with name d0ra04110f-u18.jpg 86
10 graphic file with name d0ra04110f-u19.jpg 2.5 graphic file with name d0ra04110f-u20.jpg 64
11 graphic file with name d0ra04110f-u21.jpg 4 graphic file with name d0ra04110f-u22.jpg 87
12 graphic file with name d0ra04110f-u23.jpg 3.5 graphic file with name d0ra04110f-u24.jpg 55
13 graphic file with name d0ra04110f-u25.jpg 2 graphic file with name d0ra04110f-u26.jpg 90
a

All reactions were conducted in methanol at RT, with N-Boc substrate (1 equiv.), (COCl)2 (3 equiv.).