Deprotection of structurally diverse N-Boc-amines.
Entrya | Substrate (a) | Time/h | Product (b) | Yield (%) |
---|---|---|---|---|
1 |
![]() |
2 |
![]() |
70 |
2 |
![]() |
1.5 |
![]() |
87 |
3 |
![]() |
1.5 |
![]() |
83 |
4 |
![]() |
1 |
![]() |
80 |
5 |
![]() |
2 |
![]() |
83 |
6 |
![]() |
3 |
![]() |
78 |
7 |
![]() |
1.5 |
![]() |
76 |
8 |
![]() |
1.5 |
![]() |
81 |
9 |
![]() |
1 |
![]() |
86 |
10 |
![]() |
2.5 |
![]() |
64 |
11 |
![]() |
4 |
![]() |
87 |
12 |
![]() |
3.5 |
![]() |
55 |
13 |
![]() |
2 |
![]() |
90 |
All reactions were conducted in methanol at RT, with N-Boc substrate (1 equiv.), (COCl)2 (3 equiv.).