Table 2.

Reviews on the cognitive and psychological burdens of ADT

Study	Design	Results
Casey et al. [17], 2012	review of 9 studies on neuropsychological symptoms: 4 quantitative non-RCTs, 3 reviews, and 1 cohort study	significant prevalence of dementia and cognitive decline
Donovan et al. [18], 2015	review of 12 studies on neuropsychological symptoms: 8 quantitative non-RCTs, 3 reviews, and 1 cohort study	significant prevalence of dementia and cognitive decline
Rhee et al. [19], 2015	review of 4 studies on neuropsychological symptoms: 1 quantitative non-RCTs, 1 review, and 2 RCTs	significant prevalence of dementia and cognitive decline
Cherrier et al. [21], 2020	review of 47 studies on neuropsychological symptoms: 32 quantitative non-RCTs, 7 reviews, 2 RCTs, 3 cohort studies, and 1 qualitative study	significant prevalence of depression, equivocal prevalence of dementia and cognitive decline
Treanor et al. [22], 2017	review of 28 studies	significant prevalence (10–69%) of cognitive decline
Mundell et al. [23], 2017	review of 11 longitudinal studies	significant prevalence of decline in multiple cognitive domains in many studies
McGinty et al. [24], 2014	review of 14 longitudinal comparative studies with objective neuropsychological data	significant cognitive deficits only in visuomotor tasks
Sun et al. [26], 2018	review of 26 studies: 2 prospective and 4 retrospective studies were analyzed	no significant prevalence of cognitive decline
Jamadar et al. [25], 2012	review of 11 studies: 1 RCT, 1 observational study, and 9 non-RCT quantitative studies	significant cognitive deficits only in spatial memory, and perhaps verbal memory
Wu et al. [27], 2017	review of 6 studies: 4 review studies and 2 RCTs	possible cognitive deficits
McHugh et al. [6], 2018	review of 7 studies for cognitive impairment (1 RCT and 6 non-RCTs) and 4 observational studies for dementia	possible cognitive deficits
Nead et al. [20], 2017	review of 9 comparative studies	possible increased dementia risk

RCT = Randomized controlled trial.