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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: J Mol Med (Berl). 2020 Jun 18;98(7):1021–1034. doi: 10.1007/s00109-020-01926-7

Fig. 4.

Fig. 4

Primary HSC activates by miRNAs in HC-EVs. a Pie chart of specific 344 genes (fold change > 2) in HSCs from AH mice and 67 down- or 21 upregulated with miRNAs in HC-EVs as prediction. b Protein interaction of 67 downregulated genes in HSCs from AH mice regulated by 17 upregulated miRNA in AH-HC-EVs as prediction using STRINGS. c Fold change of Nr1d2 mRNA expression in primary HSCs with negative miRNAs (Cont), and miR-27 plus miR-181. d Immunoblotting of Nr1d2 protein expression in primary HSCs with negative miRNAs (Cont), and miR-27 plus miR-181. e Quantification of Nr1d2 protein expression from immunoblotting in primary HSCs with negative miRNAs (Cont), and miR-27 plus miR-181. *P < 0.05. Values are mean ± SEM