Table 2. Treatment-Related Adverse Events.

Adverse event	Voxelotor 1,500 mg	Voxelotor 900 mg	Placebo
	(N = 88)	(N = 92)	(N = 91)
Diarrhea	11 (12.5%)	8 (8.7%)	3 (3.3%)
Nausea	6 (6.8%)	6 (6.5%)	5 (5.5%)
Abdominal pain	6 (6.8%)	6 (6.5%)	1 (1.1%)
Rash	7 (8.0%)	2 (2.2%)	4 (4.4%)
Headache	5 (5.7%)	3 (3.3%)	3 (3.3%)
Abdominal pain upper	2 (2.3%)	2 (2.2%)	2 (2.2%)
Vomiting	1 (1.1%)	3 (3.3%)	4 (4.4%)
Dermatitis acneform	1 (1.1%)	1 (1.1%)	0
Hypoesthesia	1 (1.1%)	0	1 (1.1%)
Migraine	1 (1.1%)	0	1 (1.1%)
Fatigue	0	2 (2.2%)	0
Pyrexia	0	2 (2.2%)	0
AST increased	0	2 (2.2%)	0
Decreased appetite	0	2 (2.2%)	0
Paresthesia	0	1 (1.1%)	1 (1.1%)
Pruritus	0	1 (1.1%)	1 (1.1%)
Dizziness	0	0	3 (3.3%)

Note. Adverse events between each of the groups did not differ significantly. The most common side effects were diarrhea, nausea, and abdominal pain. AST = aspartate aminotransferase. Information from Vichinsky et al. (2019).