Table 2. AmCAD-UT Diagnostic performance at different adjusted settings.
| AmCAD-UT Setting | TIRADS | SEN % (CI) | SPE (%) (CI) | ᵻPPV (%) (CI) | ᵻNPV% (CI) | ᵻDA (%) (CI) | AUROC (CI) |
|---|---|---|---|---|---|---|---|
| Default | ACR-4 | 79.6 (70.3; 87.1) | 43.0 (33.5; 52.9) | 56.1 (51.3; 60.8) | 69.7 (59.5; 78.3) | 60.5 (53.4; 67.2) | .72 (.65; .79) |
| ATA-4 | 69.4 (59.3; 78.3) | 66.4 (56.6; 75.2) | 65.4 (58.4; 71.8) | 70.3 (63.1; 76.7) | 67.8 60.9; 74.1) | .73 (.66; .80) | |
| BTA-4 | 66.3 (56.1; 75.6) | 60.8 (50.8; 70.1) | 60.8 (54.0; 67.1) | 66.3 (58.9; 73.0) | 63.4 (56.4; 70.0) | .66 (.59; .74) | |
| EU-4 | 82.7 (73.7; 89.6) | 42.1 (32.6; 52.0) | 56.6(52.1; 61.1) | 72.6 (62.0; 81.2) | 61.5 (54.4 to 68.2) | .65 (.58; .71) | |
| Kwak-4b | 76.5 (66.9; 84.5) | 54.2 (44.3; 63.9) | 60.5 (54.8; 65.9) | 71.6 (62.9; 79.0) | 64.5 (57.9; 71.4) | .74 (.67; .80) | |
| KSThR-4 | 77.6 (68.0; 85.4) | 50.5 (40.6; 60.3) | 58.9 (53.5; 64.1) | 71.1 (61.9; 78.8) | 63.4 (56.4; 70.0) | .70 (.63; .76) | |
| Adjusted1 | ACR-4 | 74.5 (64.7; 82.8) | 48.6 (38.8; 58.5) | 57.0 (51.6; 62.3) | 67.5 (58.5; 75.5) | 61.0 (53.9; 67.7) | .67 (.60; .74) |
| ATA-4 | 70.4 (60.3; 79.2) | 67.3 (57.6; 76.1) | 66.4 (59.3; 72.7) | 71.3 (64.0; 77.6) | 68.8 (62.0; 75.1) | .71 (.64; .78) | |
| BTA-4 | 69.4 (59.3; 78.3) | 58.9 (49.9; 68.3) | 60.7 (54.3; 66.8) | 67.7 (60.0; 74.6) | 63.9 (56.9; 70.5) | .67 (.59; .74) | |
| EU-4 | 81.6 (72.5; 88.7) | 46.7 (37.0; 56.6) | 58.4 (53.5; 63.2) | 73.5 (63.6; 81.5) | 63.4 (56.4; 70.0) | .66 (.59; .73) | |
| Kwak-4b | 71.4 (61.4; 80.1) | 57.0 (47.1; 66.5) | 60.3 (54.2; 66.2) | 68.5 (60.5; 75.6) | 63.9 (56.9; 70.5) | .68 (.61; .75) | |
| KSThR-4 | 71.4 (61.4; 80.1) | 58.9 (49.0; 68.3) | 61.4 (55.1; 67.3) | 69.2 (61.3; 76.2) | 64.9 (57.9; 71.4) | .70 (.63; .76) | |
| Adjusted2 | ACR-4 | 61.2 (50.9; 70.9) | 57.9 (48.0; 67.4) | 57.1 (50.4; 63.7) | 62.0 (54.8; 68.7) | 59.5 (52.5; 66.3) | .62 (.55; .70) |
| ATA-4 | 44.9 (34.8; 55.3) | 78.5 (69.5; 85.9) | 65.7 (55.6; 74.5) | 60.9 (55.9; 65.6) | 62.4 (55.4; 69.1) | .59 (.51; .67) | |
| BTA-4 | 56.1 (45.7; 66.1) | 64.5 (54.7; 73.5) | 59.1 (51.5; 66.4) | 61.6 (55.2; 67.6) | 60.5 (53.4; 67.2) | .60 (.53; .68) | |
| EU-4 | 71.4 (61.4; 80.1) | 55.1 (45.2; 64.8) | 59.3 (53.3; 65.1) | 67.8 (59.6; 75.1) | 62.9 (55.9; 69.6) | .65 (.57; .72) | |
| Kwak-4b | 50.0 (39.7; 60.3) | 68.2 (58.5; 76.9) | 59.0 (50.6; 67.0) | 59.8 (54.1; 65.4) | 59.5 (52.5; 66.3) | .61 (.54; .68) | |
| KSThR-4 | 59.2 (48.8; 69.0) | 62.6 (52.7; 71.8) | 59.2 (51.9; 66.1) | 62.6 (55.9; 68.9) | 61.0 (53.9; 67.7) | .62 (.55; .69) | |
| Adjusted3 | ACR-4 | 78.5 (69.1; 86.2) | 41.1 (31.7; 51.1) | 55.0 (50.3; 59.6) | 67.7 (57.4; 76.5) | 59.0 (52.0; 65.8) | .67 (.60; .74) |
| ATA-4 | 44.9 (34.8; 55.3) | 78.5 (69.5; 85.9) | 65.7 (55.6; 74.5) | 60.9 (55.9; 65.6) | 62.4 (55.4; 69.1) | .58 (.50; .66) | |
| BTA-4 | 56.1 (45.7; 66.1) | 64.5 (54.7; 73.5) | 59.1 (51.5; 66.4) | 61.6 (55.2; 67.6) | 60.5 (53.4; 67.2) | .62 (.55; .70) | |
| EU-4 | 82.7 (73.7; 89.6) | 42.1 (32.6; 52.0) | 56.6 (52.1; 61.1) | 72.6 (62.0; 81.2) | 61.5 (54.4; 68.2) | .63 (.56; .69) | |
| Kwak-4b | 63.3 (52.9; 72.8) | 57.0 (47.1; 66.5) | 57.4 (50.8; 63.7) | 62.9 (55.5; 69.7) | 60.0 (53.0; 66.8) | .64 (.57; .71) | |
| KSThR-4 | 77.6 (68.0; 85.4) | 43.9 (34.3; 53.9) | 55.9 (50.9; 60.7) | 68.1 (58.3; 76.6) | 60.0 (53.0; 66.8) | .63 (.57; .70) |
ᵻPPV, NPV and DA values were not calculated based on prevalence.