Table 3. Pairwise comparison of TIRADS diagnostic performance in CAD-differentiation of malignant and benign thyroid nodules at different settings.
| TIRADS Pairs | Performance measures (p-values) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Default | Adjusted 1 | Adjusted 2 | Adjusted 3 | |||||||||
| SEN* | SPEC* | AUROC | SEN* | SPEC* | AUROC | SEN* | SPEC* | AUROC | SEN* | SPEC* | AUROC | |
| ATA—ACR | .041 | .000 | .826 | 1.000 | .000 | .262 | .003 | .000 | .546 | .000 | .000 | .079 |
| ATA—BTA | 1.000 | 1.000 | .158 | 1.000 | .605 | .951 | .151 | .004 | .393 | .305 | .027 | .080 |
| ATA—EU | .001 | .000 | .051 | .001 | .000 | .873 | .000 | .000 | .224 | .000 | .000 | .057 |
| ATA—Kwak | .539 | .054 | .795 | 1.000 | .183 | .391 | 1.000 | .120 | .497 | .002 | .000 | .120 |
| ATA—KSThR | .248 | .002 | .409 | 1.000 | .605 | .094 | .016 | .001 | .992 | .000 | .000 | .073 |
| ACR—BTA | .001 | .000 | .019 | 1.000 | .183 | .338 | 1.000 | 1.000 | .814 | .000 | .000 | .427 |
| ACR—EU | 1.000 | 1.000 | .001 | .530 | 1.000 | .268 | .289 | 1.000 | .310 | 1.000 | 1.000 | .377 |
| ACR—Kwak | 1.000 | .108 | .289 | 1.000 | .605 | .490 | .151 | .120 | .686 | .023 | .006 | .204 |
| ACR—KSThR | .013 | .000 | .248 | 1.000 | .183 | .732 | 1.000 | 1.000 | .554 | 1.000 | 1.000 | .284 |
| BTA—EU | .442 | .000 | .530 | .005* | .046 | .860 | .007 | .238 | .091 | .000 | .000 | .865 |
| BTA—Kwak | .07* | .018 | .000 | 1.000* | 1.000 | .486 | 1.000 | 1.000 | .818 | 1.000 | 1.000 | .522 |
| BTA—KSThR | .206 | .206 | .168 | 1.000 | 1.000 | .115 | 1.000 | 1.000 | .343 | .000 | .000 | .712 |
| EU—Kwak | 1.000 | .054 | .000 | .040 | .183 | .472 | .000 | .011 | .159 | .001 | .013 | .694 |
| EU—KSThR | 1.000 | .657 | .022 | .040 | .046 | .140 | .075 | .806 | .169 | 1.000 | 1.000 | .720 |
| Kwak—KSThR | 1.000 | 1.000 | .030 | 1.000 | 1.000 | .411 | .528 | 1.000 | .604 | .047 | .053 | .816 |
*adjusted p values with Bonferroni correction for multiple tests comparisons.