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. 2021 Jan 15;7(3):eabc4897. doi: 10.1126/sciadv.abc4897

Fig. 4. HDAC6 interactome shows binding with glycolytic enzymes.

Fig. 4

(A) Proteomic workflow. (B) Heatmap of z-score log-transformed ion current intensities of significantly enriched proteins of HDAC6 immunoprecipitation. (C) Volcano plot illustrating the proteins interacting with HDAC6. (D) Significantly enriched KEGG pathways from HDAC6-interacting proteins. (E) Significantly enriched KEGG pathways from the 15 overlapping proteins from HDAC6 IP and acetylation experiments. Glycolytic pathway showing the proteins that HDAC6 interacts with and the proteins that have increased acetylation following BAS-2 treatment or HDAC6 KD. (F) Analysis of the expression of ALDOA, GAPDH, ENO1, LDHA, and LDHB in patients with TNBC in published RNA-sequencing data from TCGA. IHC, immunohistochemistry; ALDOA, aldolase A; ENO1, enolase 1; LDHA, lactate dehydrogenase A.