Figure 2. Liver function in PCSK9^Q152H-expressing subjects and family controls.

Correlations between age and the circulating liver enzymes lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (GGT) for carriers of the PCSK9^Q152H variant and family member controls. Squares represent men; circles represent women. Homozygous Q152H subjects (HH) are in red, heterozygous Q152H (QH) subjects are half black, and family controls (QQ) are in white. Second-order quadratic correlation is shown for the entire cohort. All data are presented as mean ± SD and were analyzed by unpaired, 2-tailed Student’s t test.