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. 2021 Jan 19;131(2):e128650. doi: 10.1172/JCI128650

Figure 8. Circulating anti-GRP78 autoantibodies are elevated in the blood of patients with NASH, but not in carriers of the PCSK9Q152H variation.

Figure 8

(A) ELISAs were used to measure plasma levels of anti-GRP78 autoantibodies in healthy controls (n = 12) and in patients with NASH (n = 9). (B) Anti-GRP78 autoantibodies were then examined in the plasma of heterozygous (QH; n = 12) and homozygous (HH; n = 2) carriers of the PCSK9Q152H mutation as well as in noncarrier WT family siblings (QQ; n = 15). Values are expressed as mean ± SD. *P < 0.05. ANOVA was used for all statistical comparisons (A and B).