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. 2021 Jan 19;131(2):e144336. doi: 10.1172/JCI144336

Figure 2. Inflammatory pathways of IL-36 and IL-36R.

Figure 2

(A) IL-36 agonists stimulate inflammatory and epithelial cells, activating the NF-κB pathway, leading to the production and secretion of inflammatory cytokines creating a feedback loop. (B) IL-36 antagonists inhibit the binding of the IL-36 co-receptor, truncating the signaling pathway. IL-1RAcP, IL-1 receptor accessory protein IL-1R3; MyD88, myeloid differentiation primary response 88; AP-1, activator protein 1; IRAKs, interleukin-1 receptor–associated kinases.