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. 2021 Jan 19;131(2):e141935. doi: 10.1172/JCI141935

Figure 5. Healthy and allergic twins exhibit differential enrichment in fecal metabolic pathways.

Figure 5

(A) Of 36 samples, 33 metabolites were more abundant in the healthy (n = 13) group relative to the allergic (n = 23) group. Metabolites are shown on the row in the format of “COMP_ID|Biochemical_Name|Super_Pathway|Sub_Pathway.” Sample IDs are shown on the column, with annotation bars above the heatmap indicating concordant/discordant twin members, sex, and zygosity. (B) Of 36 samples, 64 metabolites were more abundant in the allergic group (n = 23) relative to the healthy (n = 13) group. Same annotations as in A. In A and B, 2-tailed Welch’s 2-sample t test was used on all samples (P < 0.10) and unadjusted P value thresholds were used to filter for individual metabolites of interest. After FDR correction, no individual metabolites passed the FDR cutoff of 0.10 threshold, potentially due to small sample sizes.