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. 2021 Jan 19;131(2):e141837. doi: 10.1172/JCI141837

Figure 6. Expression of SNP-carrying candidate genes during differentiation of human iPSCs and in pediatric and adult aortic tissue.

Figure 6

(A) Schedule of directed cardiac differentiation of human iPSCs. (B) Expression of MACROD2, GOSR2, WNT3, and MSX1 during directed cardiac differentiation of human iPSCs. Data represent the mean ± SEM of at least 2 independent experiments, each run in duplicate. *P < 0.05, **P < 0.01, and ***P < 0.001 versus day 0 (D0), by unpaired, 2-tailed Student’s t test. (C) Expression of MACROD2, GOSR2, WNT3, and MSX1 in aortic tissues of pediatric patients (n = 35, 24, 23, and 6, respectively) and adult surgical patients (n = 15, 9, 10, and 20, respectively). Data represent the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, by Mann-Whitney rank-sum test.