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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Curr Biol. 2019 Dec 16;29(24):R1316–R1318. doi: 10.1016/j.cub.2019.11.024

Figure 1. Deleterious mutant mtDNA levels depend on POLG levels.

Figure 1.

Under normal conditions, a selfish genome can experience a selective advantage, comprising the majority of mtDNA copies within a cell. However, when the levels of POLG are reduced, the selective advantage is flipped, from favoring selfish mtDNA propagation to favoring the amplification of the wild-type, or functionally competent, genome.