Table 2.
Differential urinary proteins in the CBRH-7919 model.
| Accession | Protein names | Trend | Fold changes | Reported to hepatocellular carcinoma | Reported to other cancers | |||
|---|---|---|---|---|---|---|---|---|
| D5 | D7 | D14 | D28 | |||||
| Q9Y694 | Solute carrier family 22 member 7 | ↑ | 3.41 | — | — | — | Colorectal cancer | |
| P53004 | Biliverdin reductase A | ↑ | 3.34 | 2.29 | — | — | Breast cancer | |
| O76082 | Solute carrier family 22 member 5 | ↑ | 3.33 | 3.17 | 2.17 | — | Breast cancer | |
| P48507 | Glutamate–cysteine ligase regulatory subunit | ↑ | 3.13 | 2.09 | — | — | ||
| O00338 | Sulfotransferase 1C2 | ↑ | 3.08 | — | — | — | ||
| P11234 | Ras-related protein Ral-B | ↑ | 2.83 | 2.32 | — | — | Nonsmall cell lung cancer | |
| Q01523 | Neutrophil antibiotic peptide NP-4 | ↑ | 2.80 | — | — | — | ||
| B1AK53 | Espin | ↑ | 2.77 | — | — | — | ||
| Q96KP4 | Cytosolic nonspecific dipeptidase | ↑ | 2.76 | — | — | — | ||
| P0C0L4 | Complement C4 | ↑ | 2.69 | — | — | — | Serum | |
| P32929 | Cystathionine gamma-lyase | ↑ | 2.64 | 2.04 | — | — | Melanoma | |
| P14174 | Macrophage migration inhibitory factor | ↑ | 2.62 | — | — | — | Serum | Gastrointestinal tract (GIT) malignancy |
| P21399 | Cytoplasmic aconitate hydratase | ↑ | 2.57 | — | — | — | ||
| Q86YJ6 | Threonine synthase-like 2 | ↑ | 2.50 | — | — | — | ||
| P02511 | Alpha-crystallin B chain | ↑ | 2.49 | — | — | — | Tissue | Colorectal cancer |
| O94760 | Dimethylargininase-1 | ↑ | 2.48 | — | — | — | Tissue | Prostate cancer |
| Q96S37 | Solute carrier family 22 member 12 | ↑ | 2.48 | — | — | — | ||
| Q8N5Z0 | 2-Aminoadipate transaminase | ↑ | 2.47 | — | — | — | ||
| Q13113 | PDZK1-interacting protein 1 | ↑ | 2.46 | — | — | — | ||
| O95154 | Aflatoxin B1 aldehyde reductase member 3 | ↑ | 2.45 | — | — | — | ||
| O00299 | Chloride intracellular channel protein 1 | ↑ | 2.44 | — | — | — | Tissue | Gastric, colon, lung, and glioblastoma cancers |
| P13866 | Sodium/glucose cotransporter 1 | ↑ | 2.42 | — | — | — | Pancreatic cancer | |
| P36543 | V-type proton ATPase subunit E 1 | ↑ | 2.40 | — | — | — | Pancreatic cancer | |
| Q9Y696 | Chloride intracellular channel protein 4 | ↑ | 2.39 | — | — | — | ||
| Q96FL8 | Multidrug and toxin extrusion protein 1 | ↑ | 2.38 | 2.10 | — | — | ||
| O43708 | Maleylacetoacetate isomerase | ↑ | 2.36 | — | — | — | ||
| P35579 | Myosin-9 | ↑ | 2.35 | — | — | — | Colorectal cancer | |
| P26038 | Moesin | ↑ | 2.34 | — | — | — | Breast cancer | |
| P12955 | Xaa-Pro dipeptidase | ↑ | 2.33 | — | — | — | ||
| Q15599 | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | ↑ | 2.27 | — | — | — | ||
| P08133 | Annexin A6 | ↑ | 2.27 | — | — | — | Tissue | Melanoma, cervical cancer, epithelial carcinoma, breast cancer, and gastric cancer |
| P80723 | Brain acid soluble protein 1 | ↑ | 2.26 | — | — | — | Tissue | Pancreatic cancer and cervical cancer |
| P48506 | Gamma-glutamylcysteine synthetase | ↑ | 2.26 | — | — | — | ||
| Q9UHI7 | Solute carrier family 23 member 1 | ↑ | 2.25 | — | — | — | ||
| Q03154 | Aminoacylase-1A | ↑ | 2.25 | — | — | — | ||
| Q96KN2 | Beta-Ala-His dipeptidase | ↑ | 2.24 | — | — | — | Cancer cachexia | |
| O15400 | Syntaxin-7 | ↑ | 2.23 | — | — | — | ||
| Q99685 | Monoglyceride lipase | ↑ | 2.23 | — | — | — | Tissue | Gastrointestinal stromal tumor |
| Q14894 | Ketimine reductase mu-crystallin | ↑ | 2.23 | — | — | — | ||
| Q6ZQN7 | Solute carrier family 21 member 20 | ↑ | 2.23 | — | — | — | ||
| O00161 | Synaptosomal-associated protein 23 | ↑ | 2.22 | — | — | — | ||
| P49189 | 4-Trimethylaminobutyraldehyde dehydrogenase | ↑ | 2.21 | — | — | — | ||
| Q9Y6I3 | Epsin-1 | ↑ | 2.20 | — | — | 2.18 | Prostate cancer | |
| Q9UBR1 | Beta-ureidopropionase | ↑ | 2.17 | — | — | — | Serum | |
| Q14847 | LIM and SH3 domain protein1 | ↑ | 2.16 | — | — | — | Tissue | Gastric cancer |
| O43704 | Sulfotransferase family cytosolic 1B member 1 | ↑ | 2.15 | — | — | — | ||
| Q9UNQ0 | ATP-binding cassette subfamily G member 2 | ↑ | 2.15 | — | — | — | Tissue | Right-sided colon cancer |
| P30041 | Peroxiredoxin-6 | ↑ | 2.14 | — | — | — | ||
| O14745 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | ↑ | 2.13 | — | — | — | ||
| P68032 | Actin, alpha cardiac muscle 1 | ↑ | 2.12 | — | — | — | Glioblastoma | |
| P27449 | V-type proton ATPase 16 kDa proteolipid subunit | ↑ | 2.11 | — | — | — | Prostate cancer | |
| Q5T2W1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | ↑ | 2.09 | — | — | — | ||
| Q16348 | Solute carrier family 15 member 2 | ↑ | 2.09 | — | — | — | ||
| Q9H0W9 | Ester hydrolase C11orf54 homolog | ↑ | 2.08 | — | — | — | Renal cell carcinoma | |
| P60709 | Actin, cytoplasmic 1 | ↑ | 2.08 | — | — | — | Tissue | |
| P09467 | Fructose-1,6-bisphosphatase 1 | ↑ | 2.08 | — | — | — | Tissue | |
| P46721 | Solute carrier organic anion transporter family member 1A1 | ↑ | 2.07 | — | — | — | ||
| P05062 | Fructose-bisphosphate aldolase B | ↑ | 2.07 | — | — | — | ||
| P29972 | Aquaporin-1 | ↑ | 2.06 | — | — | — | Tissue | Bladder, brain, breast, cervix, colon, lung, nasopharynx, and prostate cancers |
| Q08257 | Quinone oxidoreductase | ↑ | 2.03 | — | — | — | ||
| O75083 | WD repeat-containing protein 1 | ↑ | 2.03 | — | — | — | Ovarian cancer | |
| Q9H8S9 | MOB kinase activator 1A | ↑ | 2.02 | — | — | — | ||
| Q14019 | Coactosin-like protein | ↑ | 2.02 | — | — | — | Small cell lung cancer | |
| Q8TF66 | Leucine-rich repeat-containing protein 15 | ↑ | 2.02 | — | — | — | Solid tumors (e.g., breast, head and neck, lung, and pancreatic) | |
| P05090 | Apolipoprotein D | ↑ | — | 3.38 | — | 2.43 | Tissue | Breast cancer and prostate cancer |
| Q12792 | Twinfilin-1 | ↑ | — | — | 2.48 | — | Lung adenocarcinoma | |
| P55259 | Glycoprotein 80 | ↑ | — | — | 2.47 | 4.00 | ||
| P06870 | Prostatic glandular kallikrein-6 | ↑ | — | — | — | 3.37 | ||
| P02741 | C-reactive protein | ↑ | — | — | — | 2.16 | Serum | Gastric cancer |
| O00115 | Deoxyribonuclease-2-alpha | ↓ | 0.50 | — | — | — | ||
| P37173 | TGF-beta receptor type-2 | ↓ | 0.49 | — | — | — | ||
| Q9BRK5 | 45 kDa calcium-binding protein | ↓ | 0.49 | — | — | — | ||
| O94985 | Calsyntenin-1 | ↓ | 0.49 | — | — | — | Lung adenocarcinoma | |
| P10909 | Clusterin | ↓ | 0.48 | — | — | — | Serum | Lung adenocarcinoma |
| P07339 | Cathepsin D | ↓ | 0.47 | — | — | — | Tissue | |
| Q6P4A8 | Phospholipase B-like 1 | ↓ | 0.46 | — | — | — | ||
| P34096 | Ribonuclease 4 | ↓ | 0.44 | — | — | — | ||
| P04233 | MHC class II-associated invariant chain | ↓ | 0.42 | — | — | — | ||
| Q8NFL0 | Beta-1,3-N-acetylglucosa-minyltransferase 7 | ↓ | 0.42 | — | — | — | Breast cancer | |
| P30740 | Leukocyte elastase inhibitor A | ↓ | 0.41 | — | — | — | ||
| Q8TD33 | Secretoglobin family 1C member 1 | ↓ | 0.40 | 0.31 | — | 0.42 | ||
| Q16674 | Melanoma-derived growth regulatory protein | ↓ | 0.40 | — | — | — | ||
| P15309 | Prostatic acid phosphatase | ↓ | 0.40 | — | — | — | ||
| P01834 | Ig kappa chain C region, A allele | ↓ | 0.40 | 0.46 | 0.49 | — | ||
| P01859 | Ig gamma-2A chain C region | ↓ | 0.38 | — | — | — | ||
| Q14315 | Filamin-C | ↓ | 0.38 | 0.49 | — | — | Tissue | Prostate cancer |
| P16444 | Dipeptidase 1 | ↓ | 0.38 | — | — | — | Colorectal cancer | |
| P09237 | Matrilysin | ↓ | 0.38 | — | — | — | Tissue | |
| P27797 | Calreticulin | ↓ | 0.37 | 0.42 | — | — | ||
| Q13217 | DnaJ homolog subfamily C member 3 | ↓ | 0.36 | — | — | — | ||
| Q9UGM3 | Deleted in malignant brain tumors 1 protein | ↓ | 0.36 | — | — | — | Tissue | |
| Q9NZU0 | Leucine-rich repeat transmembrane protein FLRT3 | ↓ | 0.35 | 0.47 | — | — | ||
| Q08188 | Protein-glutamine gamma-glutamyltransferase E | ↓ | 0.34 | — | — | — | ||
| Q3LXA3 | Triokinase/FMN cyclase | ↓ | 0.33 | 0.18 | 0.13 | — | ||
| Q9BY76 | Angiopoietin-related protein 4 | ↓ | 0.29 | — | — | — | Serum | Colorectal cancer |
| P08118 | Beta-microseminoprotein | ↓ | 0.23 | 0.16 | 0.23 | — | Prostate cancer | |
| P15086 | Carboxypeptidase B | ↓ | 0.21 | — | — | — | ||
| Q99895 | Chymotrypsin-C | ↓ | 0.19 | — | — | — | ||
| P34913 | Bifunctional epoxide hydrolase 2 | ↓ | 0.18 | 0.32 | — | — | ||
| P05109 | Protein S100-A8 | ↓ | 0.16 | 0.29 | — | — | Breast cancer | |
| P06702 | Protein S100-A9 | ↓ | 0.14 | 0.23 | — | — | Urine | Esophageal adenocarcinoma |
| Q9UPX8 | SH3 and multiple ankyrin repeat domains protein 2 | ↓ | 0.09 | — | — | — | ||
| P36896 | Activin receptor type-1B | ↓ | — | 0.49 | — | 0.42 | ||
| P08253 | 72 kDa type IV collagenase | ↓ | — | 0.48 | — | 0.50 | Rectal cancer, laryngeal cancer | |
| P02760 | Protein AMBP | ↓ | — | 0.48 | 0.47 | — | ||
| Q6UY14 | ADAMTS-like protein 4 | ↓ | — | 0.47 | — | — | ||
| Q8N8N7 | Prostaglandin reductase 2 | ↓ | — | 0.45 | — | — | ||
| Q9Y678 | Coatomer subunit gamma-1 | ↓ | — | 0.45 | — | 0.30 | ||
| Q13145 | BMP and activin membrane-bound inhibitor homolog | ↓ | — | 0.43 | 0.50 | 0.29 | Tissue | Melanoma, colorectal cancer |
| Q66K79 | Carboxypeptidase Z | ↓ | — | 0.43 | — | 0.22 | Tissue | |
| P48745 | CCN family member 3 | ↓ | — | 0.42 | 0.41 | 0.44 | Tissue | Breast cancer, gastric cancer |
| P09382 | Galectin-1 | ↓ | — | 0.40 | — | — | Tissue | Gastric cancer, colorectal cancer, and pancreatic ductal adenocarcinoma |
| Q03403 | Trefoil factor 2 | ↓ | — | 0.33 | 0.39 | 0.34 | Tissue | Colorectal cancer |
| P0CE71 | Oncomodulin | ↓ | — | — | 0.47 | — | ||
| Q9UBC9 | Cornifin-A | ↓ | — | — | 0.45 | — | ||
| O95388 | WNT1-inducible-signaling pathway protein 1 | ↓ | — | — | 0.43 | — | Oral squamous cell carcinoma | |
| P49221 | Protein-glutamine gamma-glutamyltransferase 4 | ↓ | — | — | 0.35 | — | Prostate cancer | |
| P02452 | Collagen alpha-1 | ↓ | — | — | 0.22 | 0.16 | Colorectal cancer | |
| P57740 | Nuclear pore complex protein Nup107 | ↓ | — | — | 0.14 | 0.35 | ||
| P35443 | Thrombospondin-4 | ↓ | — | — | — | 0.49 | Tissue | Gastric cancer |
| P49747 | Cartilage oligomeric matrix protein | ↓ | — | — | — | 0.48 | Tissue | Breast cancer and prostate cancer |
| O15197 | Ephrin type-B receptor 6 | ↓ | — | — | — | 0.48 | Colorectal cancer | |
| P35613 | Basigin | ↓ | — | — | — | 0.47 | ||
| P16112 | Aggrecan core protein | ↓ | — | — | — | 0.47 | ||
| Q04721 | Neurogenic locus notch homolog protein 2 | ↓ | — | — | — | 0.46 | Laryngeal squamous cell carcinoma | |
| Q96CG8 | Collagen triple helix repeat-containing protein 1 | ↓ | — | — | — | 0.43 | ||
| Q14112 | Nidogen-2 | ↓ | — | — | — | 0.43 | Serum | Ovarian cancer |
| Q12805 | EGF-containing fibulin-like extracellular matrix protein 1 | ↓ | — | — | — | 0.42 | Meningioma | |
| Q96IU4 | Protein ABHD14B | ↓ | — | — | — | 0.42 | ||
| Q9NP85 | Podocin | ↓ | — | — | — | 0.41 | ||
| O60462 | Neuropilin-2 | ↓ | — | — | — | 0.39 | Tissue | Nonsmall cell lung cancer, squamous cell carcinoma, and melanoma |
| O95336 | 6-Phosphogluconolactonase | ↓ | — | — | — | 0.39 | Breast cancer, nonsmall cell lung cancer, and ovarian cancer | |
| P11684 | Uteroglobin | ↓ | — | — | — | 0.21 | Prostate cancer | |
Note. — indicates no data reach the criteria compared with control. The results of two parts (reported to be related to hepatocellular carcinoma and other diseases) are annotated from previous studies.