Table 3.
Differential urinary proteins in the RH-35 model.
| Accession | Protein names | Trend | Fold change | Reported to hepatocellular carcinoma | Reported to other cancers | |||
|---|---|---|---|---|---|---|---|---|
| D5 | D7 | D14 | D28 | |||||
| Q03154 | Aminoacylase-1A | ↑ | 2.38 | — | — | — | ||
| Q66K79 | Carboxypeptidase Z | ↑ | 2.33 | — | — | 0.49 | Tissue | |
| P02763 | Alpha-1-acid glycoprotein | ↑ | 2.18 | — | — | — | Serum | Bladder cancer and lung cancer |
| P05090 | Apolipoprotein D | ↑ | 2.11 | — | — | — | Tissue | Prostate cancer and breast cancer |
| Q9UP38 | Frizzled-1 | ↑ | 2.03 | — | — | — | Follicular thyroid carcinoma | |
| P29972 | Aquaporin-1 | ↑ | 2.03 | — | — | — | Tissue | Bladder cancer, brain cancer, and breast cancer |
| P09488 | Glutathione S-transferase Mu 2 | ↑ | — | 2.02 | 2.17 | 3.58 | Nonsmall cell lung cancer | |
| Q9H3Z4 | DnaJ homolog subfamily C member 5 | ↑ | — | — | 2.05 | 3.24 | ||
| P06870 | Prostatic glandular kallikrein-6 | ↑ | — | — | — | 5.44 | ||
| P31639 | Sodium/glucose cotransporter 2 | ↑ | — | — | — | 3.10 | ||
| P08754 | Guanine nucleotide-binding protein G | ↑ | — | — | — | 2.87 | ||
| Q15833 | Syntaxin-binding protein 2 | ↑ | — | — | — | 2.74 | ||
| O94832 | Unconventional myosin-Id | ↑ | — | — | — | 2.35 | ||
| O95968 | Prostatic steroid-binding protein C2 | ↑ | — | — | — | 2.23 | ||
| Q9H2G2 | STE20-like serine/threonine-protein kinase | ↑ | — | — | — | 2.02 | Tissue | Glioma |
| O14773 | Tripeptidyl peptidase 1 | ↑ | — | — | — | 2.02 | Tissue | |
| P02144 | Myoglobin | ↑ | — | — | — | 2.01 | Lung adenocarcinoma and breast cancer | |
| Q9H6B4 | CXADR-like membrane protein | ↓ | 0.49 | — | — | — | ||
| Q9Y2T3 | Guanine deaminase | ↓ | 0.45 | — | — | — | Serum | Gastric cancer |
| Q92932 | Receptor-type tyrosine-protein phosphatase N2 | ↓ | 0.45 | 0.39 | — | 0.48 | GRN-associated frontotemporal dementia | |
| P15309 | Prostatic acid phosphatase | ↓ | 0.44 | — | — | — | ||
| P34096 | Ribonuclease 4 | ↓ | 0.44 | — | — | — | ||
| Q99757 | Thioredoxin | ↓ | 0.43 | — | — | — | ||
| P61204 | ADP-ribosylation factor 3 | ↓ | 0.43 | — | — | — | ||
| Q9UGM5 | Fetuin-B | ↓ | 0.42 | — | — | — | ||
| P07384 | Calpain-1 catalytic subunit | ↓ | 0.42 | — | — | — | ||
| P05937 | Calbindin | ↓ | 0.41 | — | 0.40 | 0.37 | Lung cancer | |
| P01859 | Ig gamma-2A chain C region | ↓ | 0.39 | — | — | — | ||
| Q71U36 | Tubulin alpha-1A chain | ↓ | 0.39 | — | — | — | Renal cell carcinoma | |
| P37837 | Transaldolase | ↓ | 0.39 | — | — | — | Serum | Ovarian cancer |
| P08962 | CD63 antigen | ↓ | 0.39 | — | — | — | Melanoma | |
| P10909 | Clusterin | ↓ | 0.39 | 0.48 | — | — | Tissue | Lung adenocarcinoma |
| P11021 | Endoplasmic reticulum chaperone BiP | ↓ | 0.37 | — | — | — | Gastric cancer | |
| Q9BS40 | Latexin | ↓ | 0.35 | — | — | — | Tissue | Gastric cancer and prostate cancer |
| Q14315 | Filamin-C | ↓ | 0.34 | — | — | — | Tissue | Prostate cancer |
| P57740 | Nuclear pore complex protein Nup107 | ↓ | 0.27 | 0.09 | 0.21 | 0.17 | ||
| P0CE71 | Oncomodulin | ↓ | 0.25 | 0.29 | 0.33 | 0.36 | ||
| P30048 | Thioredoxin-dependent peroxide reductase | ↓ | 0.23 | — | — | — | Serum | Endometrial cancer and prostate cancer |
| P27797 | Calreticulin | ↓ | 0.22 | 0.31 | — | — | ||
| P08118 | Beta-microseminoprotein | ↓ | 0.15 | — | — | 0.21 | Prostate cancer | |
| Q6P587 | Acylpyruvase FAHD1 | ↓ | — | 0.49 | — | — | ||
| P31150 | Rab GDP dissociation inhibitor alpha | ↓ | — | 0.48 | — | — | Nonsmall cell lung cancer | |
| Q5KU26 | Collectin-12 | ↓ | — | 0.46 | 0.45 | 0.47 | ||
| Q6ZVN8 | Hemojuvelin | ↓ | — | 0.46 | 0.49 | 0.49 | Tissue | |
| Q96DG6 | Carboxymethylenebutenolidase homolog | ↓ | — | 0.45 | 0.38 | 0.39 | ||
| Q9HCB6 | Spondin-1 | ↓ | — | — | 0.50 | 0.48 | Ovarian cancer | |
| Q12805 | Fibulin-3 | ↓ | — | — | 0.49 | 0.46 | Meningioma | |
| P47755 | F-actin-capping protein subunit alpha-2 | ↓ | — | — | 0.49 | 0.43 | ||
| P20333 | Tumor necrosis factor receptor 2 | ↓ | — | — | 0.48 | 0.50 | Tissue | Cholangiocarcinoma, colorectal cancer, and myeloma |
| Q9NWV4 | CXXC motif containing zinc-binding protein | ↓ | — | — | 0.48 | — | ||
| Q14332 | Frizzled-2 | ↓ | — | — | 0.43 | — | Tissue | Prostate cancer |
| O95716 | GTP-binding protein Rab-3D | ↓ | — | — | 0.41 | — | ||
| P04003 | C4b-binding protein alpha chain | ↓ | — | — | 0.39 | 0.48 | Serum | Pancreatic cancer and epithelial ovarian carcinoma |
| Q03403 | Trefoil factor 2 | ↓ | — | — | 0.36 | 0.27 | Colorectal cancer and cholangiocarcinoma | |
| Q6P1J6 | Phospholipase B1 | ↓ | — | — | 0.19 | — | ||
| P02452 | Collagen alpha-1 | ↓ | — | — | 0.19 | — | Colorectal cancer | |
| P07108 | Acyl-CoA-binding protein | ↓ | — | — | — | 0.50 | Lung cancer | |
| Q96RD6 | Pannexin-2 | ↓ | — | — | — | 0.50 | ||
| Q9Y5Q5 | Atrial natriuretic peptide-converting enzyme | ↓ | — | — | — | 0.49 | Small cell lung cancer | |
| P13591 | Neural cell adhesion molecule 1 | ↓ | — | — | — | 0.49 | Tissue | Lung cancer |
| P07602 | Prosaposin | ↓ | — | — | — | 0.48 | Gallbladder cancer and breast cancer | |
| P51884 | Lumican | ↓ | — | — | — | 0.48 | ||
| Q04771 | Activin receptor type-1 | ↓ | — | — | — | 0.48 | ||
| P13667 | Protein disulfide isomerase A4 | ↓ | — | — | — | 0.48 | Serum | |
| Q9H461 | Frizzled-8 | ↓ | — | — | — | 0.48 | Prostate cancer and renal cell carcinoma | |
| P09382 | Galectin-1 | ↓ | — | — | — | 0.47 | Tissue | Colorectal cancer and gastric cancer |
| P51687 | Sulfite oxidase | ↓ | — | — | — | 0.46 | Serum | Prostate cancer |
| P35443 | Thrombospondin-4 | ↓ | — | — | — | 0.44 | Tissue | Gastric cancer |
| P36896 | Activin receptor type-1B | ↓ | — | — | — | 0.43 | ||
| Q96CG8 | Collagen triple helix repeat-containing protein 1 | ↓ | — | — | — | 0.43 | Tissue | Osteosarcoma and ovarian cancer |
| Q8TER0 | Sushi, nidogen, and EGF-like domain-containing protein 1 | ↓ | — | — | — | 0.43 | Papillary thyroid carcinoma | |
| Q9Y678 | Coatomer subunit gamma-1 | ↓ | — | — | — | 0.42 | ||
| O60667 | Fas apoptotic inhibitory molecule 3 | ↓ | — | — | — | 0.41 | Chronic lymphocyte leukemia | |
| P16112 | Aggrecan core protein | ↓ | — | — | — | 0.40 | ||
| Q6UY11 | Protein delta homolog 2 | ↓ | — | — | — | 0.39 | Melanoma | |
| P04155 | Trefoil factor 1 | ↓ | — | — | — | 0.36 | Prostate cancer | |
| O95336 | 6-Phosphogluconolactonase | ↓ | — | — | — | 0.32 | Breast cancer, nonsmall cell lung cancer, and ovarian cancer | |
| P36957 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | ↓ | — | — | — | 0.30 | ||
| Q9BQ08 | Resistin-like gamma | ↓ | — | — | — | 0.29 | ||
| P58062 | Serine protease inhibitor Kazal-type 7 | ↓ | — | — | — | 0.21 | Esophageal cancer | |
| Q9UBC9 | Cornifin-A | ↓ | — | — | — | 0.18 | ||
Note. — indicates no data reach the criteria compared with the control. The results of two parts (reported to be related to hepatocellular carcinoma and other diseases) are annotated from previous studies.