Table 2.

Histopathological alterations of cardiac tissue in experimental groups.

Groups	Coagulative necrosis	Infiltration of inflammatory cells	Focal hemorrhage	Myocardial degeneration
Control	0 ± 0	0 ± 0	0 ± 0	0 ± 0
ATO (5 mg/kg)	1.78 ± 0.21###	2.96 ± 0.33###	2.53 ± 0.27###	2.21 ± 0.14###
PTX (100 mg/kg)	0 ± 0	0 ± 0	0 ± 0	0 ± 0
ATO + PTX (25 mg/kg)	1.63 ± 0.18	2.91 ± 0.46	2.1 ± 0.37	1.70 ± 0.36
ATO + PTX (50 mg/kg)	1.01 ± 0.14∗	1.94 ± 0.29	1.20 ± 0.42∗	1.29 ± 0.40
ATO + PTX (100 mg/kg)	0.81 ± 0.31∗∗	1.42 ± 0.18∗∗	1.41 ± 0.12∗	1.47 ± 0.23

The results are expressed as means ± SEM, n = 6 for each group. ^≠≠≠P < 0.001 vs. control group; ^∗P < 0.05 and ^∗∗P < 0.01 vs. ATO group. Statistical analysis used one-way ANOVA with Tukey's test. The microscopic observations were scored as 0 (0%), 1 (1–25%), 2 (26–50%), 3 (51–75%), and 4 (76–100%) according to the percentage of histopathological changes. ATO: arsenic trioxide (equal 5 mg/kg); PTX: pentoxifylline.