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. 2020 Dec 10;23:536–551. doi: 10.1016/j.omtn.2020.12.005

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Knockdown of Xist promotes tumor proliferation and migration

(A) The comparison of Xist expression between breast cancer tissues and adjacent tissues in TCGA dataset. (B) The comparison of Xist expression between ovarian cancer tissues and adjacent tissues in the GEO: GSE26712 dataset. MCF-7 and OV cells were cocultured with M1 conditional medium after transfected with sh-NC or sh-Xist-1 or sh-Xist-2 plasmids. (C) The cell viabilities of MCF-7 and OV cells were analyzed by MTT assays. (D) Wound-healing results showing the migration ability of MCF-7 and OV cells. (E) Transwell results showing the migration ability of MCF-7 and OV cells. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 versus sh-NC; n = 3; mean ± SD.