Table 2.

Significant covariates from univariate analysis of Cox proportional model

	na	Coefficient	Hazard ratio	P value
Cavg,t, ng/mL	421	− 0.00377	0.996355	0.1175
Ki67 score, %	351	0.0123	1.012	0.0002
Age, years	421	− 0.0195	0.981	0.004
Baseline AST, U/L	421	0.0101	1.010	0.0233
Baseline tumor size, mmb	322	0.0048	1.005	0.024
Baseline alkaline phosphatase, U/L	421	0.0013	1.001	0.0307
Baseline albumin, mg/dL	421	− 0.3820	0.682	0.0483

AST aspartate aminotransferase, C_avg,t time-varying average concentration, RECIST Response Evaluation Criteria in Solid Tumors

^an values reflect the number of patients for whom the corresponding covariate was available for analysis

^bBaseline tumor size was defined as the sum of the longest diameters of non-nodal lesions and short axis for nodal lesions, per RECIST guidelines