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. 2021 Jan 11;15:87–97. doi: 10.2147/DDDT.S269029

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© 2021 Zhang et al.

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The effects of Roflumilast on Doxorubicin-induced pro-inflammatory and anti-inflammatory cytokines production in H9c2 cardiac cells. Cells were treated with 5 μmol/l Doxorubicin in the presence or absence of Roflumilast (2.5, 5 μM) for 24 hours. (A) mRNA of IL-17; (B) mRNA of IL-6; (C) mRNA of TNF-α; (D) mRNA of IL-4; (E) Protein of IL-17; (F) Protein of IL-6; (G) Protein of TNF-α; (H) Protein of IL-4 (****P<0.0001 vs vehicle control; ^{##, ###}P<0.01, 0.001 vs Doxorubicin treatment).