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. 2021 Jan 15;11:1532. doi: 10.1038/s41598-021-81122-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental and computational diffusion profiles. (a) Experimental images of fluorescent HDAPPs and HA-HDAPPs diffusing into organoid matrices over a 24 h period and (b) experimental images of HDAPPs and HA-HDAPPs diffusing out of organoid matrices over a 24 h period. Computational profiles were calculated for concentration of HDAPPs (c) and HA-HDAPPs (d), with the red intensity indicating higher concentrations. The red lines indicate the calculated nanoparticle concentration in comparison to the experimentally measured profiles (black lines), measured spatially at 24 h.