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. 2021 Jan 15;12:389. doi: 10.1038/s41467-020-20576-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Labeling of compounds used for stable isotope labeling in cell culture. Grey circles indicate the positions of isotopes (¹³C, ¹⁵N, or ²H/D). b Merged high resolution mass spectra of the 4 canonical nucleosides of total tRNA after labeling of HEK 293 cells with shown compounds for 7 days. Background signals are marked with asterisks. c Merged high resolution mass spectra of three exemplary modifications (m⁵C, m⁷G, and m¹A) in total tRNA after stable isotope labeling of HEK 293 cells for 7 days.