Table 2.

Analysis of the Cox Proportional Hazard Model with cluster data for bisphosphonate and non-bisphosphonate users in pSS cohorts.

Case 1: bisphosphonate users
pSS	Event	Incidence rate	IRR	95 CI for IRR	Adj. HR‡	95 CI for Adj. HR
No (Ref.)	44	1071.30	Ref		Ref
Yes	19	2133.49	1.99*	(1.16–3.41)	1.96*	(1.14–3.38)

Case 2: non-bisphosphonate users
pSS	Event	Incidence rate	IRR	95 CI for IRR	Adj. HR‡	95 CI for Adj. HR
No (Ref.)	42	1443.11	Ref		Ref
Yes	5	473.50	0.52	(0.20–1.30)	0.53	(0.22–1.28)

(1) *0.01 ≤ p < 0.05, **0.0001 ≤ p < 0.01, ***p < 0.0001. (2) ^‡ADJ. HR was adjusted by sex, comorbidities, and age at the initiation of bisphosphonate use.

pSS primary Sjogren syndrome, IRR incidence rate ratio, 95 CI 95% confidence interval, Adj. HR adjusted hazard ratio, Ref reference.