Table 2.

A summary of the 5 candidates EPO mutants, their relative effect on immunogenicity, bioactivity and predicted MHC binding.

EPO mutant	Core binding site(s)	Predicted MHC binding (nM)	Bioactivity relative to EPO-WT (%)	Immunogenicity with significant lower T cell response in HLA-DRB1*09-positive group
EPO-1.2	VLRGQALLV LRSLTTLLR	36.28 16.22	5.9	** p value = 0.00382
EPO-3.1	LRSLTTLLR	16.22	43.1	**** p value = 0.00002
EPO-3.2	LRSLTTLLR	16.22	24.3	**** p value = 0.00004
EPO-3.3	LRSLTTLLR	16.22	22.9	*** p value = 0.00031
EPO-4.1	LRSLTTLLR LLRALGAQK	16.22 14.2	3.2	** p value = 0.00116