Figure 4.

Myostatin exon skipping after repeated PMO injections increases muscle mass, but not insulin sensitivity, in high-fat diet-fed mice. (a,b) Muscle mass of TA (a) and EDL (b) muscles from chow- and HFD-fed mice after repeated i/m PMO or saline administration. (c) Glucose uptake into TA muscle per unit muscle mass during the IPITT. (d) GLUT4 transcript levels in TA muscle. Data are shown as individual data points with bars indicating the mean values and data points from the same animals connected by lines. *p < 0.05, **p < 0.01 vs. Saline within same diet group. ⁺⁺⁺p < 0.001 vs. saline in the other diet group. N = 10 per group.