Fig. 2.

Correlation of immunological biomarkers with pathologic response. (A) Multi-marker assessments showed higher levels of Th1 cells and CD8+ central memory T-cells at baseline associated with superior pCR rate (p = 0406) in patients while higher TIM3 expression on CD4+ and CD8+ T-cells at baseline correlated with gross viable tumor (no pathologic response) (p = 0472). (B) Individually, lower levels of Tregs (p = 0.0407) at 6 months as well as higher levels of central memory CD8 cells (p = 0.0098) at 12 months post treatment correlated with pCR.